Journal of Parkinson's Disease - Volume Pre-press, issue Pre-press

Authors: Mohamed, Nguyen-Vi | Larroquette, Frédérique | Beitel, Lenore K. | Fon, Edward A. | Durcan, Thomas M.

Article Type: Research Article

Abstract: Studying Parkinson’s disease (PD) in the laboratory presents many challenges, the main one being the limited availability of human cells and tissue from affected individuals. As PD is characterized by a loss of dopaminergic (DA) neurons in the brain, it is nearly impossible for researchers to access and extract these cells from living patients. Thus, in the past PD research has focused on the use of patients’ post-mortem tissues, animal models, or immortalized cell lines to dissect cellular pathways of interest. While these strategies deepened our knowledge of pathological mechanisms in PD, they failed to faithfully capture key mechanisms at …play in the human brain. The emergence of induced pluripotent stem cell (iPSC) technology is revolutionizing PD research, as it allows for the differentiation and growth of human DA neurons in vitro , holding immense potential not only for modelling PD, but also for identifying novel therapies. However, to reproduce the complexity of the brain’s environment, researchers are recognizing the need to further develop and refine iPSC-based tools. In this review, we provide an overview of different systems now available for the study of PD, with a particular emphasis on the potential and limitations of iPSC as research tools to generate more relevant models of PD pathophysiology and advance the drug discovery process. Show more

Keywords: Stem cells, CRISPR, co-cultures, neuronal organoids, Parkinson’s disease, cell therapy

DOI: 10.3233/JPD-181515

Citation: Journal of Parkinson's Disease, vol. Pre-press, no. Pre-press, pp. 1-17, 2019

Authors: Markaki, Ioanna | Klironomos, Stefanos | Svenningsson, Per

Article Type: Research Article

Abstract: Cerebral small vessel disease (SVD), often manifesting as white matter lesions (WMLs), and Parkinson’s disease (PD) are common disorders whose prevalence increases with age. Vascular risk factors contribute to SVD, but their role in PD is less clear. The study objective was to investigate the frequency and grade of WMLs in PD, and their association with clinical and biochemical parameters. In 100 consecutive patients, we found that increasing WML severity was independently associated with increased age and lower cerebrospinal fluid amyloid-β1-42 . Longitudinal studies would increase understanding of the interplay between WMLs and amyloid pathology in PD.

Keywords: Parkinson’s disease, cerebral small vessel disease, amyloid-beta, cerebrospinal fluid

DOI: 10.3233/JPD-181486

Citation: Journal of Parkinson's Disease, vol. Pre-press, no. Pre-press, pp. 1-7, 2018

Authors: Rosqvist, Kristina | Odin, Per | Hagell, Peter | Iwarsson, Susanne | Nilsson, Maria H. | Storch, Alexander

Article Type: Correction

DOI: 10.3233/JPD-189380

Citation: Journal of Parkinson's Disease, vol. Pre-press, no. Pre-press, pp. 1-2, 2018

Article Type: Correction

DOI: 10.3233/JPD-189001

Citation: Journal of Parkinson's Disease, vol. Pre-press, no. Pre-press, pp. 1-1, 2018