Clinical Hemorheology and Microcirculation - Volume 8, issue 1
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Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of
Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of
Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to
Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of
Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
Abstract: Studies were carried out to evaluate the effects of different methylxanthines on the erythrocyte deformability (E.D.) using two techniques of filtration through polycarbonate 5 µm pore diameter. 1. Initial flow rate filtration. 2. Initial pressure rate filtration induced at constant flow. Correlation assays between structure and effects of these methylxanthines on the E.D. are discussed. Initial flow rate filtration. Initial pressure rate filtration induced at constant flow.
Abstract: Resorption of subcutaneously administered insulin is known to be under dependence of various factors, including changes in local blood flow. This study was undertaken in order to determine whether hemorheologic disturbances may also modify it. Fourteen insulin-dependent diabetics (4 females and 10 males, age 24 to 70 yr) received subcutaneously 10 units of porcine monocomponent insulin (Actrapid MC, Novo) and blood increases in both total and free insulinemia were measured over 2 hours. Rheological parameters studied during the test were: Ca) blood filterability (according to Reid et al) and (b) washed erythrocyte filterability. In six patients who had lowered blood…filterability, the increase in total insulinemia was significantly impaired. Therefore, among various other factors, blood rheology might play a role in insulin resorption kinetics, possibility by modulating blood flow in subcutaneous microvessels.
Abstract: Abnormal rheological properties of red cells are important in a wide range of microvascular diseases. A beneficial effect of beta-blocking drugs has been noted in the secondary prevention of myocardial infarction. We therefore investigated the influence of these drugs on red cell rheology. Erythrocyte filtrability was significantly increased after incubation with Metoprolol, there was no effect, however, after incubation with Propranolol or Timolol. The exact mechanism of this effect is still unknown. Differences regarding cardioselectivity do not seem to be involved. Lipophilic agents, however, induce changes within the erythrocyte membrane leading to a constant cell volume.
Keywords: Hemorheological properties, Effect of Beta-Blocking agents
Abstract: Erythrocyte-endothelial interaction has been postulated as a potential etiologic factor of vascular pathology in diabetes mellitus. To examine this hypothesis, red cells from diabetics with a wide range of vascular disease were allowed to contact cultured endothelial monolayers and then were subjected to shear stresses calculated to be in the physiological range for capillaries, venules and arterioles to assess whether erythrocyte-endothelial binding is sustained in conditions simulating in vivo flow. Diabetic red cells, like control cells, do not demonstrate adherence to cultured endothelium under conditions which resemble in vivo flow dynamics in venous,capillary or arterial regions of the…circulation. This suggests that erythrocyte-endothelial adherence is not likely to be the primary factor in initiation of vessel wall degeneration.
Abstract: Sixteen arteritic patients at stage II, III and IV according to Fontaine, were treated by isovolemic hemodilution. The procedure consisted of the daily withdrawal of 500 ml of blood, which is replaced by 250 ml of a 4% solution of human albumin and 250 ml of Dextran 40. The procedure was applied, on average, for three days in succession until the patient’s hematocrit reached 0.30. The therapy was carried out over a total of 8 weeks, with fortnightly hemodilution sessions. Improvement was observed in clinical factors: a 100% increase in treadmill performance, disappearance of decubitus pain and wound healings. The…following biological parameters were studied: plasma albumin and fibrinogen levels, plasma and blood viscosity, red blood cells aggregation index, platelet aggregation, plasma β -thromboglobulin level, platelet MDA and nucleotides concentrations. The results revealed that by the 56th day of treatment, 8 patients had improved, 4 remained stationary and 4 were deteriorated, regardless of etiology or stage of arteritis. With regard to biological parameters (which before IHD, were always impaired), they improved after the first IHD procedure, then returned after two months of IHD Trial to levels some half-way between the values measured before HID and normal values. Physiopathological implications of these clinical and biological results are discussed.
Keywords: Isovolemic hemodilution, arteriopathy, human albumin, hemorheology, platelet activation, Dextran