Effects of methylxanthines on tile erythrocyte deformability: Correlation assays between structure and activities

Article type: Research Article

Authors: Thao Chan, H.M.^a | Franzini, E.^b | Thao Chan, M.^b

Affiliations: [a] Laboratoire d’Hématologie (Service du Pr Andreux), Faculté de Pharmacie, Rue J. Clément, 92290 Chatenay Malabry, France | [b] Laboratoire d’Hémorhéologie, Laboratoires Hoechst, Tour Nobel, 1 Terrasse Belline, 92800 Puteaux, France

Note: [] Accepted by: Editor M.R. Boisseau (Received in final form by Executive Editorial Office 9.10.1987)

Abstract: Studies were carried out to evaluate the effects of different methylxanthines on the erythrocyte deformability (E.D.) using two techniques of filtration through polycarbonate 5 µm pore diameter. 1.Initial flow rate filtration.2.Initial pressure rate filtration induced at constant flow. Correlation assays between structure and effects of these methylxanthines on the E.D. are discussed.

Keywords: Methylxanthines, erythrocyte deformability

DOI: 10.3233/CH-1988-8105

Journal: Clinical Hemorheology and Microcirculation, vol. 8, no. 1, pp. 17-22, 1988