A method of semi-quantifying β-AP in brain PET-CT 11C-PiB images
Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 2nd International Conference on Biomedical Engineering and Biotechnology, 11–13 October 2013, Wuhan, China
Affiliations: Institute of Biomedical Engineering, School of Communication and Information Engineering, Shanghai University, Shanghai, China | PET Center, Huashan Hospital, Fudan University, Shanghai, China
Note: [] Corresponding authors: Jiehui Jiang and Zhuangzhi Yan, E-mail: [email protected] and [email protected]. This investigation is sponsored by National Natural Science Foundation of China (NSFC 61171146).
Note: [] Corresponding authors: Jiehui Jiang and Zhuangzhi Yan, E-mail: [email protected] and [email protected]. This investigation is sponsored by National Natural Science Foundation of China (NSFC 61171146).
Abstract: Alzheimer's disease (AD) is a common health problem for elderly populations. Positron emission tomography-computed tomography (PET-CT)11C-PiB for beta-P (amyloid-β peptide, β-AP) imaging is an advanced method to diagnose AD in early stage. However, in practice radiologists lack a standardized value to semi-quantify β-AP. This paper proposes such a standardized value: SVβ−AP. This standardized value measures the mean ratio between the dimension of β-AP areas in PET and CT images. A computer aided diagnosis approach is also proposed to achieve SVβ−AP. A simulation experiment was carried out to pre-test the technical feasibility of the CAD approach and SVβ−AP. The experiment results showed that it is technically feasible.
