Change in refractive index of muscle tissue during laser-induced interstitial thermotherapy

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 2nd International Conference on Biomedical Engineering and Biotechnology, 11–13 October 2013, Wuhan, China

Article type: Research Article

Authors: Chen, Na^; | Chen, Meimei | Liu, Shupeng | Guo, Qiang | Chen, Zhenyi | Wang, Tingyun

Affiliations: Key Lab of Specialty Fiber Optics and Optical Access Networks, School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China

Note: [] Corresponding author. Email: [email protected]

Abstract: This paper presents a long-period fiber-grating (LPG) based Michelson interferometric refractometry to monitor the change in refractive index of porcine muscle during laser-induced interstitial thermotherapy (LITT). As the wavelength of RI interferometer alters with the change in refractive index around the probe, the LPG based refractometry is combined with LITT system to measure the change in refractive index of porcine muscle when irradiated by laser. The experimental results show the denaturation of tissue alters the refractive index significantly and the LPG sensor can be applied to monitor the tissue state during the LITT.

Keywords: Refractive index, laser-induced interstitial thermotherapy, long-period fiber grating, Michelson interferometer

DOI: 10.3233/BME-130872

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 1, pp. 807-813, 2014