Fabrication of anticoagulation layer on titanium surface by sequential immobilization of poly (ethylene glycol) and albumin

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 2nd International Conference on Biomedical Engineering and Biotechnology, 11–13 October 2013, Wuhan, China

Article type: Research Article

Authors: Pan, Chang-Jiang^; | Hou, Yan-Hua | Zhang, Bin-Bin | Zhang, Lin-Cai

Affiliations: Jiangsu Provincial Key Laboratory for Interventional Medical Devices, Huaiyin Institute of Technology, Huai'an 223003, P.R. China

Note: [] Address for correspondence: Dr. Chang-Jiang Pan, 1 meicheng road, huai'an 223003, P.R. China. Tel.: +86-517-83559130; Fax: +86-517-83559150; E-mail: [email protected]

Abstract: This paper presents a simple method to sequentially immobilize poly (ethylene glycol) (PEG) and albumin on titanium surface to enhance the blood compatibility. Attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) analysis indicated that PEG and albumin were successfully immobilized on the titanium surface. Water contact angle results showed a better hydrophilic surface after the immobilization. The immobilized PEG or albumin can not only obviously prevent platelet adhesion and activation but also prolong activated partial thromboplastin time (APTT), leading to the improved anticoagulation. Moreover, immobilization of albumin on PEG-modified surface can further improve the anticoagulation. The approach in the present study provides an effective and efficient method to improve the anticoagulation of blood-contact biomedical devices such as coronary stents.

Keywords: Titanium, surface modification, anticoagulation, PEG, albumin

DOI: 10.3233/BME-130868

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 1, pp. 781-787, 2014