Hyaluronic acid as an internal phase additive to obtain ofloxacin/PLGA microsphere by double emulsion method

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 2nd International Conference on Biomedical Engineering and Biotechnology, 11–13 October 2013, Wuhan, China

Article type: Research Article

Authors: Wu, Gang^{; ;} | Chen, Long^; | Li, Hong | Wang, Ying-jun^;

Affiliations: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China | National Engineering Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China | Department of Materials Science and Engineering, Jinan University, Guangzhou 510632, China

Note: [] Corresponding author. E-mail: [email protected]

Abstract: Hyaluronic acid (HA) was used as an internal phase additive to improve the loading efficiency of ofloxacin, a hydrophilic drug encapsulated by hydrophobic polylactic-co-glycolic acid (PLGA) materials, through a double emulsion (water-in-oil-in-water) solvent extraction/evaporation method. Results from laser distribution analysis show that polyelectrolyte additives have low impact on the average particle size and distribution of the microspheres. The negatively charged HA increases the drug loading efficiency as well as the amount of HA in microspheres. Burst release can be observed in the groups with the polyelectrolyte additives. The release rate decreases with the amount of HA inside the microspheres in all negatively charged polyelectrolyte-added microsphere groups.

Keywords: Drug release, microsphere, ofloxacin, hyaluronic acid

DOI: 10.3233/BME-130863

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 1, pp. 751-756, 2014