In-line phase contrast micro-CT reconstruction for biomedical specimens

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 2nd International Conference on Biomedical Engineering and Biotechnology, 11–13 October 2013, Wuhan, China

Article type: Research Article

Authors: Fu, Jian^; | Tan, Renbo

Affiliations: Research Center of Digital Radiation Imaging and Biomedical Imaging, Beijing University of Aeronautics and Astronautics, 100191 Beiijng, People's Republic of China. E-mail: [email protected], [email protected]

Note: [] Corresponding author. E-mail: [email protected].

Abstract: X-ray phase contrast micro computed tomography (micro-CT) can non-destructively provide the internal structure information of soft tissues and low atomic number materials. It has become an invaluable analysis tool for biomedical specimens. Here an in-line phase contrast micro-CT reconstruction technique is reported, which consists of a projection extraction method and the conventional filter back-projection (FBP) reconstruction algorithm. The projection extraction is implemented by applying the Fourier transform to the forward projections of in-line phase contrast micro-CT. This work comprises a numerical study of the method and its experimental verification using a biomedical specimen dataset measured at an X-ray tube source micro-CT setup. The numerical and experimental results demonstrate that the presented technique can improve the imaging contrast of biomedical specimens. It will be of interest for a wide range of in-line phase contrast micro-CT applications in medicine and biology.

Keywords: X-ray in-line phase contrast imaging, micro computed tomography, reconstruction algorithm, X-ray tube source

DOI: 10.3233/BME-130827

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 1, pp. 431-437, 2014