Affiliations: 10th Research Group, National Institute for Research in Inorganic Materials, 1-1, Namiki, Tsukuba-city, Ibaraki 305, Japan | Department of Mineral Resources Engineering, School of Science and Engineering, Waseda University, 3-4-1, Okubo, Shinjuku-ku, Tokyo 160, Japan | Division of Inorganic Materials, Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, 2-3-10, Surugadai, Kanda, Chiyoda-ku, Tokyo 101, Japan | International Apatite Institute, Plaza-Ochanomizu Building 5F, 2-1, Surugadai, Kanda, Chiyoda-ku, Tokyo 101, Japan
Note: [] Please send correspondence and reprints requests to Masanori Kikuchi, Ph.D., 10th Research Group, National Institute for Research in Inorganic Materials 1-1, Namiki, Tsukuba-city, Ibaraki 305, Japan. Tel.: +81 298 51 3351; Fax: +81 298 51 8291; E-mail: [email protected].
Abstract: Barium hydroxyapatite (Ba10(PO4)6(OH)2, Ba-HAp) was synthesized by a wet method using Ba(OH)2·8H2O and (NH4)2HPO4 as starting materials. The Ba-HAp obtained had a Ba/P atomic ratio of 1.76 and contained CO3 groups. The Ba-HAp was sintered at 1073 K for 12 hours. The sintered Ba-HAp had a three point bending strength of 29 MPa and Young's modulus of 27 GPa. Cytotoxicity of the sintered bodies and particles was tested using L-cells. The sintered Ba-HAp showed no cytotoxicity, and the cells were closely in contact with the surfaces of sintered Ba-HAp. Morphological observation of the cell around the Ba-HAp particles also showed no cytotoxicity. However, cell growth was inhibited by Ca adsorption on the Ba-HAp particles. These results suggested that the Ba-HAp had no cytotoxicity and can be applied as a bioactive X-ray opaque material.
