Biodistribution imaging of magnetic particles in mice: X-ray scanning analytical microscopy and magnetic resonance imaging

Issue title: Selected papers presented at the International Symposium on Nanotoxicity Assessment and Biomedical Environmental Application of Fine Particles and Nanotubes, Hokkaido, Japan, 16–17 June 2008, Part 2

Article type: Research Article

Authors: Abe, Shigeaki^; | Kida, Ikuhiro | Esaki, Mitsue^; | Akasaka, Tsukasa | Uo, Motohiro | Hosono, Toshiaki | Sato, Yoshinori | Jeyadevan, Balachandran | Kuboki, Yoshinori^; | Morita, Manabu | Tohji, Kazuyuki | Watari, Fumio

Affiliations: Department of Biomedical Materials and Engineering, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan | Department of Oral Physiology, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan | Department of Preventive Dentistry, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan | Department of Oral Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan | Graduate School of Environmental Studies, Tohoku University, Sendai, Japan | Koken Bioscience Institute, Tokyo, Japan

Note: [] Address for correspondence: Shigeaki Abe, Department of Biomedical Materials and Engineering, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan. E-mail: [email protected].

Abstract: Nano-sized particles have received much attention in view of their varied application in a wide range of fields. For example, magnetite (Fe3O4) nanoparticles have been investigated for various medical applications. In this study, we visualized the distribution of administered magnetic nanoparticles in mice using both X-ray scanning analytical microscopy (XSAM) and magnetic resonance imaging (MRI). After administration, the nanoparticles were rapidly dispersed via the blood circulation, and reached the liver, kidney and spleen. Using the XSAM and MRI methods in a complementary fashion, the biodistribution of nano-sized magnetite particles was successfully visualized.

Keywords: Biodistribution, magnetic resonance imaging, nano magnetite

DOI: 10.3233/BME-2009-0583

Journal: Bio-Medical Materials and Engineering, vol. 19, no. 2-3, pp. 213-220, 2009