Injectable biphasic calcium phosphate bioceramic: The HYDROS^® concept

Issue title: Selected papers presented at the International Symposium on Nanotoxicity Assessment and Biomedical Environmental Application of Fine Particles and Nanotubes, Hokkaido, Japan, 16–17 June 2008, Part 1

Article type: Research Article

Authors: Baroth, Serge^{; ;} | Bourges, Xavier | Goyenvalle, Eric | Aguado, Eric | Daculsi, Guy

Affiliations: Biomatlante SAS, Vigneux de Bretagne, France | University of Nantes, INSERM U791, School of Dental Surgery, Nantes, France | LBBTO, Veterinary School, Nantes, France

Note: [] Address for correspondence: Serge Baroth, Biomatlante SAS, 44360 Vigneux de Bretagne, France. Tel.: +33 2 40 41 29 16; Fax: +33 2 40 08 37 12; E-mail: [email protected].

Abstract: A new biphasic calcium phosphate ceramic material has been developed in our laboratory. It is composed of 60% of hydroxyapatite and 40% of β-tricalcium phosphate, based on three granulometries (submicron, round microporous 80–200 μm and macro microporous 0.5–1 mm particles) and hydrated with water leading the formation of a putty filler for bone repair. Biocompatibility and osteogenicity were tested by filling femoral epiphyses critical size bone defect and lumbar muscles in rabbit. After 3, 6 and 12 weeks of implantation, explants were treated for histology. Results revealed the biocompatibility of the material and intensive resorption of the submicron particle fraction followed by important bone ingrowth whereas osteoconduction was provided by the larger particles.

Keywords: Biphasic calcium phosphate, ceramic, nano-microparticles, resorption, bone ingrowth

DOI: 10.3233/BME-2009-0565

Journal: Bio-Medical Materials and Engineering, vol. 19, no. 1, pp. 71-76, 2009