Detraining effects on the mechanical properties and morphology of rat tibiae

Article type: Research Article

Authors: Fujie, Hiromichi^; | Miyagaki, Junpei | Terrier, Alexandre | Rakotomanana, Lalao^; | Leyvraz, Pierre‐Francois | Hayashi, Kozaburo

Affiliations: Division of Mechanical Science, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560‐8531, Japan | Biomechanical Engineering Laboratory, Department of Physics, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland | Hospital for Orthopedics, Lausanne, Switzerland | Division of Bioengineering, Graduate School of Engineering Science, Osaka University, Japan

Note: [] Corresponding author (present address): Hiromichi Fujie, Ph.D., Biomechanics Laboratory, Department of Mechanical Engineering, Kogakuin University, Hachioji, Tokyo 192‐0015, Japan. Tel.: +81 426 28 4494; Fax: +81 426 27 2360; E‐mail: [email protected].

Abstract: To study bone adaptation to detraining in growing rats, nine weeks‐old immature female Wistar rats (n=110) were subjected to treadmill running programs (30 or 60 minutes‐a‐day) for up to 15 weeks, followed by unrestricted cage activities for the subsequent 15 weeks. The results revealed that (1) the cross‐sectional area and mechanical properties of the midshaft bone significantly increased in response to running exercise, (2) its structural properties remained unchanged after the cessation of exercise, whereas the material properties returned to control level at a relatively early stage, (3) in the metaphysis, cortical bone area remained unchanged but trabecular bone area decreased in response to running exercise, (4) both areas slightly increased after the cessation of exercise, and (5) the changes in the mechanical properties and morphology of bone depended upon the repetition number and/or the duration of exercise, and were larger with longer duration of exercise.

Keywords: Bone remodeling, cortical and trabecular bones, mechanical property, morphology, running exercise, detraining, rat

Journal: Bio-Medical Materials and Engineering, vol. 14, no. 2, pp. 219-233, 2004