Simulation analysis of aneurysm embolization surgery: Hemorheology of aneurysms with different embolization rates (CTA)

Article type: Research Article

Authors: Bao, Quan^a | Meng, Xin^b | Hu, Mingcheng^a | Xing, Jian^a | Jin, Dan^c | Liu, He^a | Jiang, Jie^d | Yin, Yanwei^a;

Affiliations: [a] Department of Image, Hongqi Hospital Affiliated with Mudanjiang Medical University, Mudanjiang, China | [b] Department of Image, No. 3 Hospital Affiliated with Qiqihaer Medical University, Qiqihaer, China | [c] Department of Image, No. 2 Hospital of Mudanjiang, Mudanjiang, China | [d] Department of Infectious Disease, Mudanjiang Forestry Center Hospital, Mudanjiang, China

Correspondence: [*] Corresponding author: Yanwei Yin, Department of Image, Hongqi Hospital Affiliated with Mudanjiang Medical University, No. 5 Tongxiang Road, Aimin District, Mudanjiang, 157011, China. E-mail: [email protected]

Abstract: BACKGROUND:Embolization degree acts as an important factor affecting recurrence of aneurysm. OBJECTIVE:To analyze the role of hemodynamics parameters of different degrees of embolization in the occurrence, development and post-treatment of aneurysms, and to determine the specific factors causing the occurrence and recurrence of aneurysms after hemodynamics treatment. Our study provides a theoretical basis for the prevention and treatment of aneurysms. METHODS:Computed tomography angiography data of a patient with cerebral aneurysm was used to model 0%, 24%, 52%, 84% and 100% of endovascular embolization, respectively. The time average wall shear stress, time average wall shear stress, oscillatory shear index, hemodynamics formation index and relative retentive time were used to analyze the changes of hemodynamics indexes in different embolic models. RESULTS:With the increase of embolic rate, the values of time average wall shear stress, time average wall shear stress grade and aneurysm index formation gradually increased, and the values of relative retention time gradually decreased. Oscillatory shear index was higher in patients with incomplete embolization and decreased in patients with complete embolization. CONCLUSIONS:As the degree of embolization increased, the blood flow tended to stabilize, reducing the risk of cerebral aneurysm rupture, and finding that the wall of the vessel junction was susceptible to injury.

Keywords: Intracranial aneurysm, computational fluid dynamics, embolization, numerical simulation

DOI: 10.3233/BME-211225

Journal: Bio-Medical Materials and Engineering, vol. 32, no. 5, pp. 295-308, 2021