Mechanobiology of mesenchymal stem cells: Which interest for cell-based treatment?

Issue title: Selected papers from the 6th China–France International Symposium “Stem Cells and Regenerative Medicine” and the first meeting of the France–China International CNRS Network (GDRI) CeSMeR, Nancy, 10–13 July 2016

Guest editors: J.-F. Stoltz, J. Magdalou and D. Bensoussan

Article type: Research Article

Authors: Huselstein, Céline^{a; b; c; *} | Rahouadj, R.^{b; d} | de Isla, N.^{a; b; c} | Bensoussan, D.^{a; b; c; e} | Stoltz, J.F.^{a; b; c} | Li, Y.P.^f

Affiliations: [a] UMR 7365 CNRS-Université de Lorraine, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Biopôle, 54500 Vandœuvre-lès-Nancy, France | [b] Université de Lorraine, 54000 Nancy, France | [c] FR3209 CNRS BMCT – Bio-Ingénierie Moléculaire Cellulaire et Thérapeutique, Faculté de Médecine, F-54505 Vandœuvre-lès-Nancy, France | [d] UMR 7563 CNRS-Université de Lorraine, LEMTA, Vandœuvre-lès-Nancy, France | [e] CHU de Nancy, Unité de Thérapie Cellulaire, banque de Tissus, 54500 Vandœuvre-lès-Nancy, France | [f] Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China

Correspondence: [*] Corresponding author: Céline Huselstein, UMR 7365 CNRS-UL Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA) and FR 3209 UL-CNRS Bioingénierie Moléculaire, Cellulaire et Thérapeutique 9, avenue de la forêt de Haye 54505 Vandoeuvre-lès-Nancy, France. E-mail: [email protected].

Abstract: Thanks to their immune properties, the mesenchymal stem cells (MSC) are a promising source for cell therapy. Current clinical trials show that MSC administrated to patients can treat different diseases (graft-versus-host disease (GVHD), liver cirrhosis, systemic lupus, erythematosus, rheumatoid arthritis, type I diabetes…). In this case, the most common mode of cell administration is the intravenous injection, and the hemodynamic environment of cells induced by blood circulation could interfere on their behavior during the migration and homing towards the injured site. After a brief review of the mechanobiology concept, this paper will help in understanding how the mechanical environment could interact with MSC behavior once they are injected to patient in cell-based treatment.

Keywords: Mesenchymal stem cells, cell-based treatment, mechanobiology, migration, homing

DOI: 10.3233/BME-171623

Journal: Bio-Medical Materials and Engineering, vol. 28, no. s1, pp. S47-S56, 2017