Affiliations: [a] Philips Research, Research scholar, Manipal University, India | [b] Manipal University, Manipal, India. E-mails: [email protected], [email protected]
Correspondence:
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Corresponding author: Y. Kiran Kumar, Philips Innovation Campus, Manyata Tech Park, Nagawara, Bangalore, India. E-mail: [email protected].
Abstract: Cerebral arteriovenous malformations (CAVM) are congenital lesions that contain a cluster of multiple arteriovenous shunts (NIDUS). Cardiac arrhythmia in CAVM patients causes irregular changes in blood flow and pressure in the NIDUS area. This paper proposes the framework for creating the lumped model of tortuous vessel structure near NIDUS based on radiological images. This lumped model is to analyze flow variations, with various combinations of the transient electrical signals, which simulate similar conditions of cardiac arrhythmia in CAVM patients. This results in flow variation at different nodes of the lumped model. Here we present two AVM patients with evaluation of 150 vessels locations as node points, with an accuracy of 93%, the sensitivity of 95%, and specificity of 94%. The calculated p-value is smaller than the significance level of 0.05.
