In vivo study of osteogenerating properties of calcium-phosphate coating on titanium alloy Ti–6Al–4V

Article type: Research Article

Authors: Gnedenkov, Sergey V.^a | Sinebryukhov, Sergey L.^a | Puz′, Artyom V.^a | Egorkin, Vladimir S.^{a; *} | Kostiv, Roman E.^b

Affiliations: [a] Institute of Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 159, Prosp. 100-letiya Vladivostoka, Vladivostok 690022, Russia | [b] Pacific State Medical University, 2, Prosp. Ostryakova, Vladivostok, Russia

Correspondence: [*] Corresponding author. Tel.: +7-902-5562027; E-mail: [email protected].

Abstract: The method of formation of bioactive calcium-phosphate coating on medical titanium alloy Ti–6Al–4V (3.5–5.3% V; 5.3–6.8% Al; balance –Ti) by plasma electrolytic oxidation (PEO) has been developed. Evaluation of osteogenerating properties of the coating at fractures of the shaft of the femur on Wistar line laboratory rats has been performed. It has been established that the calcium-phosphate PEO coating accelerates osteogenesis and promotes the formation of a pronounced periosteal callus in the fracture area. The presence of calcium phosphates in the PEO coating surface layer significantly accelerates the growth of bone tissue on the titanium surface.

Keywords: Calcium-phosphate coatings, titanium alloy Ti–6Al–4V, plasma electrolytic oxidation, implant, osteogenesis

DOI: 10.3233/BME-161608

Journal: Bio-Medical Materials and Engineering, vol. 27, no. 6, pp. 551-560, 2016