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Down-regulation of AKT combined with radiation-induced autophagy and apoptosis roles in MCF-7 cells

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 4th International Conference on Biomedical Engineering and Biotechnology, 18–21 August 2015, Shanghai, China

Guest editors: Feng Liu, Dong-Hoon Lee, Ricardo Lagoa and Sandeep Kumar

Article type: Research Article

Authors: Zhang, Jinga | Zhao, Dalib | Xie, Zhongweib | Qi, Yalia; *

Affiliations: [a] Department of Epidemiology, School of Public Health, Beihua University, Jilin 132011, Jilin, China | [b] Jilin Entry-exit Inspection and Quarantine, Jilin 132011, Jilin, China

Correspondence: [*] Address for correspondence: Yali Qi, Department of Epidemiology, School of Public Health, Beihua University, Jilin 132011, Jilin, China. Tel.: 0432-64608337; Fax: 0432-64608116; E-mail: [email protected].

Note: [1] This research was supported by Jilin province education department science and technology research projects (2014-192). The authors declare that they have no competing interests in this research.

Keywords: Autophagy, apoptosis, radiation, Akt, breast cancer

DOI: 10.3233/BME-151532

Journal: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S2259-S2265, 2015

Published: 2015
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Autophagy is an evolutionarily conservation process whereby cytoplasm and cellular organelles are degraded in lysosomes for amino acid and energy recycling. Autophagy concurrent with radiotherapy has emerged as a novel approach in breast cancer treatment. Our studies conclude that autophagy and apoptosis can be induced by radiation and inhibition of autophagy can increase apoptosis. In addition, Akt is a molecule that down-regulates autophagy and apoptosis; blocking Akt can enhance autophagy and apoptosis induced by radiation in MCF-7 cells. Akt could become a new focus in breast cancer radiotherapy.

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