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PGBL inhibits the RAW 264.7 cells to express inflammatory factor

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 4th International Conference on Biomedical Engineering and Biotechnology, 18–21 August 2015, Shanghai, China

Guest editors: Feng Liu, Dong-Hoon Lee, Ricardo Lagoa and Sandeep Kumar

Article type: Research Article

Authors: Zhang, Chunmeia | Lin, Linghuia | Li, Guirongb | Ma, Jianana | Han, Xua | Fei, Ruia; *

Affiliations: [a] Department of Cell Biology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China | [b] Department Of Ophthalmology, Second Hospital, Jilin University, Changchun 130041, P.R. China

Correspondence: [*] Address for correspondence: Rui Fei, Department of Cell Biology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China, Tel.: +86 0431 85619473; Fax: +86 0431 85619105; E-mail: [email protected].

Keywords: LPS, PGBL, TNF-α, IL-6, NF–κB

DOI: 10.3233/BME-151512

Journal: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S2069-S2075, 2015

Published: 2015
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Polysaccharides derived from Ginkgo biloba leaf (PGBL) is a kind of active ingredient came out from ginkgo biloba leaf extractions. Previous studies have shown that PGBL has a good anti-inflammatory effect. However, the mechanism is not clear. This study is to investigate the modulated immunity effect of PGBL on RAW264.7 cells. Here we showed that lipopolysaccharide (LPS) induces the expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and this induction can be repressed by PGBL treatment both in protein level and mRNA level, and PGBL strongly reduced the translocation of nuclear factor (NF)-κB to the cell nucleus. These findings demonstrate that PGBL can decrease the sensitivity of monocytes to LPS, and PGBL has applications in systemic inflammation and immune diseases.

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