You are viewing a javascript disabled version of the site. Please enable Javascript for this site to function properly.
Go to headerGo to navigationGo to searchGo to contentsGo to footer
In content section. Select this link to jump to navigation

Temporal integration reflected by frequency following response in auditory brainstem

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 4th International Conference on Biomedical Engineering and Biotechnology, 18–21 August 2015, Shanghai, China

Guest editors: Feng Liu, Dong-Hoon Lee, Ricardo Lagoa and Sandeep Kumar

Article type: Research Article

Authors: Xu, Qina; b | Ye, Datiana; b; *

Affiliations: [a] Department of Biomedical Engineering, Tsinghua University, Beijing, 100084, China | [b] Research Center of Biomedical Engineering, Graduate School at Shenzhen Campus of Tsinghua University, Shenzhen 518055, China

Correspondence: [*] Address for correspondence: Datian Ye, Research Center of Biomedical Engineering, Graduate School at Shenzhen Campus of Tsinghua University, Shenzhen 518055, China. Tel.: 13855197357; E-mail: [email protected].

Note: [1] The authors report no declarations of interest upon this paper.

Keywords: Auditory temporal integration (ATI), frequency following response (FFR), cortical response P1, loudness

DOI: 10.3233/BME-151368

Journal: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S767-S778, 2015

Published: 2015
Get PDF open access

Auditory temporal integration (ATI) has been widely described in psychoacoustic studies, especially for loudness perception. Loudness increases with increasing sound duration for durations up to a time constant about 100 ~ 200 ms, and then loudness becomes saturated with more duration increase. However, the electrophysiological mechanism underlying the ATI phenomenon has not been well understood. To investigate ATI at the brainstem level of auditory system and its relationship to cortical and behavioral ATI, frequency follow response (FFR) was acquired in our study. Simultaneously, ATI in auditory cortex was evaluated by cortical response P1. Behavioral loudness and electrophysiological measures were estimated from normal-hearing young adults for vowel /a/ whose durations varied from 50 ms to 175 ms. Significant effects of stimulus duration were found both on FFR and P1 amplitudes. Linear regression analysis revealed that as stimulus duration increased, brainstem FFR amplitude was significantly associated with cortical P1 amplitude and behavioral loudness, which confirmed the existence of temporal integration in auditory brainstem. Moreover, behavioral loudness ATI was better predicted using brainstem and cortical measures together than merely using each one separately, indicating an interplay and coordination for ATI across the three levels along auditory pathway.

Show more