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Influence of the hypothalamic paraventricular nucleus (PVN) on heart rate variability (HRV) in rat hearts via electronic lesion

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 4th International Conference on Biomedical Engineering and Biotechnology, 18–21 August 2015, Shanghai, China

Guest editors: Feng Liu, Dong-Hoon Lee, Ricardo Lagoa and Sandeep Kumar

Article type: Research Article

Authors: Deng, Xina | Feng, Xuhuib | Li, Senc | Gao, Yad | Yu, Bingzhie | Li, Gensonga; b; *

Affiliations: [a] The Experimental Center of Functional Subjects, College of Basic Medical Scientific Research, China Medical University, P.R. China | [b] Department of Physiology, College of Basic Medical Scientific Research, China Medical University, P.R. China | [c] Department of Neurology, The First Affiliated Hospital, China Medical University, P.R. China | [d] 96K 7-years, China Medical University, P.R. China | [e] Department of Biochemistry and Molecular Biology, College of Basic Medical Scientific Research, China Medical University, P.R. China

Correspondence: [*] Address for correspondence: Gensong Li, The Experimental Center of Functional Subjects, College of Basic Medical Scientific Research, China Medical University, P.R. China. Tel.: 0086(0)13386885803; E-mail: [email protected].

Note: [1] Xin Deng and Xuhui Feng equally contributed to this article.

Note: [2] This work was supported by the National Nature Science Foundation of China Grants (No. 81370712 and 81270654) and no other potential conflict of interest relevant to this article was reported.

Keywords: Heart rate variability (HRV), paraventricular nucleus (PVN), Rat, electrical lesion

DOI: 10.3233/BME-151338

Journal: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S487-S495, 2015

Published: 2015
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Previous literatures have indicated that hypothalamic paraventricular nucleus (PVN) neurons are important for regulating the level of sympathetic and vagal nervous activity. Sympathovagal balance is closely related to heart rate variability (HRV). However, it still requires further elucidation regarding the effect of PVN on HRV by regulating sympathovagal balance. To detect the influence of the PVN on HRV, we evaluated the changes in time domain (including standard deviation of the R-R intervals (SDNN), and the root mean square of successive differences (RMSSD)) and frequency domain (including low frequency (LFnu), high frequency (HFnu) and the ratio of LF/HF) in HRV upon appropriate electronic stimulation, and lesions on the PVN of the rat in vivo. Cardiac vagal modulation was evaluated by HFnu; sympathetic modulation was evaluated by LFnu. Sympathovagal balance was evaluated by LF/HF and SDNN. Upon electronic stimulating (less than 0.6 mA) to the PVN of rats, we found that LFnu and HFnu changed correspondingly but recovered after the stimulation. When the PVN of the rats was injured, the RR intervals were enhanced with the rats’ unilaterally or bilaterally injured PVN, especially the bilateral lesion. Meanwhile, LFnu, LF/HF and SDNN decreased gradually, accompanied with an increase of HFnu levels. So these PVN changes may indicate alterations of the sympathovagal balance.

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