Affiliations: Shanghai MicroPort Medical (Group) Co., Ltd, Shanghai, China | Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China | Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China
Note: [] Address for correspondence: Jiang Chang, Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China. Tel.: +86 21 52412804; E-mail: [email protected]
Abstract: BACKGROUND: Degradation periods of biodegradable medical devices strongly affect their clinical performance and therefore special attention has been drawn to modulate their degradation rate. OBJECTIVE: This paper presents an experimental study on the effect of hydrophobic coating on the degradation behavior of PLLA samples. METHODS: PLLA films were coated with a thin layer of PCL, and a combination of scanning electron microscopy (SEM), Ubbelohde Viscometer Capillary, and chromatograph of gel permeation (GPC) was used to evaluate the morphology and molecular weight changes of samples during degradation. In addition, the mass loss of samples was also measured during the experiment. RESULTS: PLLA samples with PCL coatings showed a slower degradation rate than those without PCL coatings, which indicated that PCL coatings could protect inside PLLA samples and slow down the degradation rate of PLLA samples. CONCLUSIONS: The results of the study suggest that hydrophobic coating on polymer materials is a useful approach to control the degradation of polymer medical device.
