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MicroRNAs: potential biomarkers for disease diagnosis

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 3rd International Conference on Biomedical Engineering and Biotechnology, 25–28 September 2014, Beijing, China

Article type: Research Article

Authors: Xu, Li | Qi, Xiuli; | Duan, Shengliang | Xie, Yumei | Ren, Xinlei | Chen, Gaoyun | Yang, Xiaocong | Han, Lili | Dong, Qirui

Affiliations: Institute of Chemical Defence, Changping District, Beijing 102205, PR China | Academy of Equipment Command and Technology, Changping District, Beijing 102249, PR China

Note: [] Corresponding author: Xiuli Qi, Institute of Chemical Defence, Changping District, Beijing 102205, PR China. Tel.: +8615810032213; E-mail: [email protected].

Keywords: MicroRNA, biomarker, disease diagnosis

DOI: 10.3233/BME-141223

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 3917-3925, 2014

Published: 2014
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Abstract

MicroRNAs (miRNAs) are a group of endogenous noncoding small RNAs characterized by high conservation; furthermore, various studies have shown the capability of miRNAs to impact diseases. For example, a study shows that cell-free miRNAs are stable in bodily fluids, which gives circulating miRNAs the ability to be potential biomarkers for noninvasive diagnosis. Additionally, accumulating studies have supported that miRNAs can function as suppressor genes, again demonstrating their effect on disease. This review introduces this particular role of miRNAs as well as analyzes the prospect of miRNAs as biomarkers and the capacity for using miRNA-based resources to benefit mankind.

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