You are viewing a javascript disabled version of the site. Please enable Javascript for this site to function properly.
Go to headerGo to navigationGo to searchGo to contentsGo to footer
In content section. Select this link to jump to navigation

Expression of Cx43 and Pax3 proteins in the human placental villi and decidua during early pregnancy

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 3rd International Conference on Biomedical Engineering and Biotechnology, 25–28 September 2014, Beijing, China

Article type: Research Article

Authors: Zhang, Jinping; | Zhang, Leijia | Liu, Xuehong | Zhou, Fuqun

Affiliations: Department of Histology and Embryology, Medical College, Shaoxing University, Shaoxing 312000, Zhejiang, China | Department of Obstetrics and Gynecology, Shaoxing Municipal Maternal and Children Hospital, Shaoxing 312000, Zhejiang, China

Note: [] Corresponding author: Jinping Zhang, Department of Histology and Embryology, Medical College, Shaoxing University, Shaoxing 312000, Zhejiang, China. Tel.: 0575-88345821; Fax: 0575-88062799; E-mail: [email protected].

Keywords: Connexin43, pax3, Chorionic villi, decidua, Immunohistochemistry

DOI: 10.3233/BME-141214

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 3841-3847, 2014

Published: 2014
Get PDF open access

Abstract

To study the expression and roles of Connexin43 (Cx43) and Paired-box3 (Pax3) proteins in the human Chorionic villi and decidua during early pregnancy, Cx43 and Pax3 protein expression in the human placental villi and decidua at 5–7 weeks of early pregnancy was studied by immunohistochemistry (SABC). Integrated optical density (IOD) of Cx43 and Pax3 protein expression was obtained by using special image analysis software. Cx43 and Pax3 proteins were expressed in all trophoblastic cells, cells of villi central axis and decidual cells. IOD of Cx43 and Pax3 proteins expressed in the syncytiotrophoblast decreased from 5 to 7 weeks, while Cx43 and Pax3 expressed in cytotrophoblast cells and decidual cells showed increased IOD during the same period. The differences between any two groups were statistically significant (P<0.05). Cx43 and Pax3 proteins were expressed during differentiation and development of placental villous cells in early phases of pregnancy. We propose that Cx43 and Pax3 may participate in endometrial decidualization and the regulation of trophoblastic invasion and differentiation. It is likely that Cx43 and Pax3 play critical roles in cell proliferation and differentiation during the processes of chorionic villi initiation/development and placental morphogenesis.

Show more