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Predicting the minimal inhibitory concentration of fluoroquinolones for Escherichia coli using an accumulation model

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 3rd International Conference on Biomedical Engineering and Biotechnology, 25–28 September 2014, Beijing, China

Article type: Research Article

Authors: Zhang, Wen | Wang, Chenyin | Tam, Kin Y.;

Affiliations: Faculty of Health Sciences, University of Macau, Macau, China

Note: [] Corresponding author: Kin Y. Tam, Faculty of Health Sciences, University of Macau, Macau, China. Tel.: +853 8822 4988; Fax: +853 8822 2314; E-mail: [email protected].

Keywords: Fluoroquinolones, minimal inhibitory concentration, Escherichia coli, physicochemical parameters

DOI: 10.3233/BME-141203

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 3745-3751, 2014

Published: 2014
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Abstract

The objective of this study is to evaluate whether the accumulation model developed by Zarfl et al. (2008) could be used to predict the minimal inhibitory concentration (MIC) of a group of antibacterial fluoroquinolones (FQs) for Escherichia coli (E. coli). Our model, which is based on the “Fick-Nernst-Planck” equation and the permeability of the neutral and charged species as well as the physicochemical parameters of the FQs, could predict 1/MIC90 using a linear function. It is envisaged that in the drug development projects of new FQs, the accumulation model described in this study could be utilized as an effective tool to enable early assessment of MIC value using physiochemical parameters.

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