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Gender differences in presentation and outcome of patients with Cushing's disease in Han Chinese

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 3rd International Conference on Biomedical Engineering and Biotechnology, 25–28 September 2014, Beijing, China

Article type: Research Article

Authors: Huan, Cheng | Qu, Yuanming | Ren, Zongming;

Affiliations: Shandong Provincial Hospital Affiliated to Shandong University, Ji'nan 250021, P.R. China | College of Life Science, Shandong Normal University, Ji'nan 250014, P.R. China

Note: [] Corresponding author: Zongming Ren, College of Life Science, Shandong Normal University, Ji'nan 250014, P.R. China. Tel.: +86-531-86182515; Fax: +86-531-86182515; E-mail: [email protected].

Keywords: Cushing's disease, gender differences, transsphenoidal surgery, CushingQoL scores

DOI: 10.3233/BME-141168

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 3439-3446, 2014

Published: 2014
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Abstract

The purpose of this study was to assess gender-related distinction in the performance of Cushing's disease (CD) regarding clinical features, radiological findings, neurological and endocrine status, surgical outcome, and quality of life in Han Chinese. A retrospective study was conducted on 87 patients treated by trans-sphenoidal surgery, between 2006 and 2011, at a single treatment center in Shandong Provincial Hospital, China. Features of CD were compared and quality of life was analyzed between genders. The female-to-male ratio was 2.78: 1. Results showed that men have a younger age of diagnosis (P<0.001), a larger adenoma diameter (P<0.001), and a higher invasion rate (P=0.032) and apoplexy rate (P=0.04) than women. To be specific, compared with women, men are more prone to suffering from osteoporosis, hypokalemia, sexual dysfunction, and hypertension (P<0.05), have significantly higher preoperative and postoperative (six months after surgery) cortisol levels (P<0.001, P=0.003) and a higher recurrence rate (30.43% vs. 7.81%; P=0.028). No significant differences were seen in the CushingQoL scores between genders. Therefore, male patients with CD need more careful and long-term follow-up than female patients.

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