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Prognostic value of SUVmax and metabolic tumor volume on 18F-FDG PET/CT in early stage non-small cell lung cancer patients without LN metastasis

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 3rd International Conference on Biomedical Engineering and Biotechnology, 25–28 September 2014, Beijing, China

Article type: Research Article

Authors: Yoo, Ie Ryung | Chung, Soo Kyo; | Park, Hye Lim | Choi, Woo Hee | Kim, Young Kyoon | Lee, Kyo Young | Wang, Young-Pil

Affiliations: Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, Korea | Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea | Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea | Department of Thoracic and Cardiovascular Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea

Note: [] Corresponding author: Soo Kyo Chung, Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, Korea. Tel.: 82-2-2258-1549; Fax: 82-2-2258-1575; E-mail: [email protected].

Keywords: Non-small-cell lung cancer, PET/CT, standardized uptake value, metabolic tumor volume, early stage

DOI: 10.3233/BME-141131

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 3091-3103, 2014

Published: 2014
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Abstract

This paper aimed to evaluate the prognostic value of maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) of the primary tumor on 18F-FDG PET/CT scan in early stage non-small cell cancer (NSCLC) patients without lymph node (LN) metastasis. In the experiment, eighty NSCLC patients pathologically staged as T1N0 or T2N0 were included (M:F=50:30; mean age, 64.8 years). All patients had preoperative 18F-FDG PET/CT scan and curative surgery. FDG uptake in the primary tumor was measured by SUVmax and MTV with various SUV threshold values. SUVmax, MTV of the primary tumor, age, tumor size, histology and differentiation grade were analyzed for association with disease-free survival (DFS). The experimental results showed that the histology types included adenocarcinoma (n=58), squamous cell carcinoma (n=20), and others (n=2); Twenty-two (27.5%) of the 80 patients had a recurrence during follow-up at a median time of 29.1 months; The median SUVmax was 5.26, and the median MTV2.5 was 2.2 cm3. Univariate analysis showed higher SUVmax (>4), greater MTV (MTV2.5 >4 cm3), and non-squamous histology were significantly associated with shorter period DFS (p=0.001, p=0.030 and p<0.001). In multivariate analysis, higher SUVmax (p=0.004) and adenocarcinoma histology (p=0.005) were associated with shorter DFS. Therefore, high SUVmax (>4) of the primary tumor on preoperative 18F-FDG PET/CT scan is an independent prognostic factor of shorter DFS in early stage of NSCLC.

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