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Effect of elevated intraocular pressure on the thickness changes of cat laminar and prelaminar tissue using optical coherence tomography

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 3rd International Conference on Biomedical Engineering and Biotechnology, 25–28 September 2014, Beijing, China

Article type: Research Article

Authors: Zhao, Qiuyun; ; | Qian, Xiuqing; | Li, Lin; | Sun, Weijian; | Huang, Shan; | Liu, Zhicheng; ;

Affiliations: School of Biomedical Engineering, Capital Medical University, Beijing 100069, China | Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing 100069, China

Note: [] Qiuyun Zhao and Xiuqing Qian contributed equally to this work.

Note: [] Corresponding author: Zhicheng Liu, School of Biomedical Engineering, Capital Medical University, Beijing 100069, China. Tel.: 086-010-83911559; Fax: 086-010-83911560; E-mail: [email protected].

Keywords: Laminar cribrosa, prelaminar tissue, curvature, high intraocular pressure, EDI-OCT

DOI: 10.3233/BME-141048

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 2349-2360, 2014

Published: 2014
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Abstract

The aim of this study was to examine shape the changes of the lamina cribrosa (LC) under different intraocular pressures (IOPs) with different periods. Images of the optic nerve head were obtained using enhanced depth imaging spectral domain optical coherence tomography (EDI SD-OCT). After an initial scan of the IOP at native pressure, subsequent scanning was taken when the IOP values reached 40, 60, 80 and 100 mm Hg. Then scans continued with the IOP maintained at 100 mm Hg for 1 hour, 2 hours, 3 hours and 4 hours. The thicknesses of the LC and prelaminar tissue were measured and the curvature of the LC was calculated. Our study found that as IOP increased, the thicknesses of both LC and prelaminar tissue decreased and the thickness variation of the LC correlated significantly with the increases of IOP when IOP was higher than 60 mm Hg. An exponential function was proposed to express the relationship between IOP and the thickness variations of LC and prelaminar tissue. Creep curves of the LC and prelaminar tissue was also obtained using the Prony model. In conclusion, both the thickness of the prelaminar tissue and LC thinned as the IOP elevated. The thickness of the LC also decreased after 4 hours of constant 100 mm Hg pressure.

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