Clinical Hemorheology and Microcirculation - Volume 8, issue 5

Authors: Kaperonis, A.A. | Chien, S.

Article Type: Research Article

Abstract: Four normal women and two heterozygous β -thalassemic women were examined throughout one or more menstrual cycles for variations in several rheological parameters and red cell metabolism during the menstrual, follicular and luteal phases. Cyclic variations were found in the physical and chemical properties of the red cells (including mean corpuscular hemoglobin concentration, intracellular contents of 2,3-diphosphoglycerate and adenosine triphosphate, and erythrocyte deformability). These physiological changes during the menstrual cycle are exaggerated in heterozygous B-thalassemic women.

Keywords: Blood Rheology, Heterozygous Thalassemia, Menstrual Cycle, Red Cell Aggregation, Red Cell Deformability, Red Cell Metabolism

DOI: 10.3233/CH-1988-8521

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 5, pp. 751-762, 1988

Authors: Koltringer, P. | Eber, O. | Lind, P. | Klima, G. | Ribitsch, V.

Article Type: Research Article

Abstract: In a series 43 patients suffering from cerebral or peripheral diseases were investigated over a period of 3 days after a single hypervolemic hemodilution with 500ml low molecular weight dextran (Rheomacrodex® ) applied within 3 hours. Changes in hematocrit, visco-elasticity of whole blood and plasma viscosity were studied. 18 to 36 hours after onset of infusion a significant increase in plasma viscosity (p ⩽ 0.001 ) and elasticity (p ⩽ 0.01 ) could be observed. Furthermore, there was a tendency towards higher hematocrit and whole blood viscosity levels. However, after 60 hours a second lower …numerical peak for hematocrit and viscosity of whole blood could be seen, which was yet above starting values. Show more

Keywords: Hemodilution, dextran, viscoelasticity, plasma viscosity, hematocrit

DOI: 10.3233/CH-1988-8522

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 5, pp. 763-771, 1988

Authors: Vaya, A. | Aznar, J. | Villa, P. | Valles, J. | Santos, M.T. | Martinez-Sales, V.

Article Type: Research Article

Abstract: The present study evaluates the whole blood filterability index (WB-FI) and the washed red blood cell filterability index (WRBC-FI) in 21 chronic cerebrovascular insufficiency (CCVI) patients and in 36 control subjects. Althoug no significant differences were found in the mean values of the two groups, approximately 30% of the patients had a decreased WB-FI. Of the 7 CCVI patients who showed reduced WB-FI, this decrease could be attributed to erythrocyte deficiency in only two of the cases. Of the 21 CCVI patients, pentoxifylline (POX) was administered to 9, dipyridamole (DIP) to 6 and POX+DIP to another 6. The changes …in WB-FI were evaluated 7, 15 and 45 days after treatment was begun. POX and DIP administered separately favoured WB-FI at 15 and 7 days respectively, but when administered together, WB-FI only increased slightly on the 45th day. Show more

Keywords: erythrocyte filterability, cerebrovascular insufficiency, pentoxifylline, dipyridamol

DOI: 10.3233/CH-1988-8523

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 5, pp. 773-778, 1988

Authors: Stone, P.C.W. | Chalder, S.M. | Stuart, J.

Article Type: Research Article

Abstract: Piracetam (2-oxo-1-pyrrolidine acetamide) has been reported to have a beneficial rheological effect on sickle cells although its mode of action has remained unclear. When the Ca2+ -ionophore A23187 was used to induce loss of K+ and water from sickle cells from 20 patients, the consequential loss of erythrocyte filterability through pores of 5 µm diameter was partially corrected by piracetam at concentrations of 0.1-100 mmol/l (p < 0.002 - < 0.02). No beneficial effect of piracetam was found when sickle cells were dehydrated using the K+ ionophore valinomycin. Piracetam therefore prevents cation (K+ ) loss, via the Gardos …channel, from Ca2+ -loaded erythrocytes and may thereby inhibit the dehydration of sickle cells. Show more

Keywords: Rheology, Erythrocyte deformability, Sickle cell anemia

DOI: 10.3233/CH-1988-8524

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 5, pp. 779-790, 1988

Authors: Ernst, E. | Schmidlechner, Ch. | Matrai, A. | Bergmann, H.

Article Type: Short Communication

Keywords: snoring, hemorheology, cardiovascular risk factors

DOI: 10.3233/CH-1988-8525

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 5, pp. 791-792, 1988

Authors: Wegener, Thomas | Sandhagen, Bo

Article Type: Short Communication

Keywords: Acetylcysteine, Immunoglobuline M, Macroglobulinaemia, Plasma viscosity, Waldenstrom’s disease

DOI: 10.3233/CH-1988-8526

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 5, pp. 793-795, 1988

Authors: Norcliffe, D. | Brown, M.J.

Article Type: Short Communication

Keywords: Erythrocyte flexibility

DOI: 10.3233/CH-1988-8527

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 5, pp. 797-800, 1988

Article Type: Announcement

DOI: 10.3233/CH-1988-8528

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 5, pp. 801-804, 1988

Article Type: Correction

DOI: 10.3233/CH-1988-8529

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 5, pp. 805-805, 1988

Authors: Ernst, E.

Article Type: Other

DOI: 10.3233/CH-1988-8530

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 5, pp. 807-814, 1988

Article Type: Other

DOI: 10.3233/CH-1988-8531

Citation: Clinical Hemorheology and Microcirculation, vol. 8, no. 5, pp. 815-818, 1988