Clinical Hemorheology and Microcirculation - Volume 34, issue 1-2
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Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of
Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of
Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to
Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of
Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
Abstract: The objective of this study is to examine roles of genistein in postmenopausal induced-endothelial dysfunction and bone loss, the ovariectomized (OVX) rat model was used. The animals were divided into three groups of sham treated with vehicle (DMSO 100 μl/day; Shamveh ), OVX treated with vehicle (OVXveh ) and OVX treated with genistein (0.25 mg/kg/day; OVXgen ). At 3 and 7 weeks after the surgery, endothelial dysfunction in mesenteric microcirculation of each group was determined by using intravital fluorescence microscopy and analyzed with digital image software. The parameters of bone mass density (BMD) and bone formation marker were represented by…percentage of ash/dry matter and osteocalcin activity (using radioimmunoassay (RIA)), respectively. Mean arterial pressures (MAP) in OVXveh groups were significantly increased compared to their aged-matched sham groups (p<0.05). Interestingly, the treatment of genistein could significantly attenuate this abnormality (p<0.001). Besides, it could increase the vascular response to acetylcholine (Ach; 10−6 M) significantly compared to OVX-rats (p<0.05). Moreover, BMD and osteocalcin activity were significantly increased in Ovxgen as well. Therefore, our findings suggested that genistein supplementation could effectively prevent endothelial dysfunction and bone loss in OVX-rat model.
Keywords: Genistein, endothelial dysfunction, bone, ovariectomized rat
Abstract: This paper was aimed to study whether vitamin C supplementation reverses the diabetes-induced endothelial cell dysfunction occurred in streptozotocin (STZ)-rats or not. The animals were divided into four groups: control and diabetes rats (DM, using iv. injection of 50 mg/kg.bw STZ), and two DM rats treated with vitamin C (1 g/l) starting on day 2 (DM + VitCday2 ) and week 6th after STZ-injection (DM + VitC6wks ). The mesenteric microcirculation was observed using fluorescence videomicroscopy. Based on the recorded videoimages, microvascular responses to acetylcholine (Ach; 10–5 M) and number densities of leukocyte adhesion in venules were evaluated using the…Global Lab II image software. In DM group, blood glucose and glycosylated hemoglobin were significantly increased, while the body weight and plasma vitamin C levels were decreased significantly compared to their controls. Ach-induced vasodilation was decreased, while the number of leukocyte adhesion was increased significantly compared to their controls (p<0.01). These abnormalities induced by DM were prevented by supplementation of vitamin C in DM + VitCday2 group. Six-weeks delayed treatment of vitamin C (DM + VitC6wks ) demonstrated increase in the Ach-induced vasodilation with significant decrease in the leukocyte adhesion. It was indicated that vitamin C supplementation could reverse diabetes-induced endothelial cell dysfunction in mesenteric microcirculation.
Abstract: Hemoglobin-Vesicles (HbV; diameter, 250 nm) are artificial O2 carriers encapsulating purified and concentrated human Hb solution in phospholipid vesicles (liposomes), and their safety and efficacy, as a transfusion alternative, have been studied. In this paper, we summarized the characteristics of HbV that have been clarified by the microcirculatory observations.