Changes of nitric oxide, oxide free radicals, and systolic arterial blood pressure in rats with experimental lymphatostatic encephalopathy

Issue title: Selected Proceedings of the 6th Asian Congress for Mirocirculation (ACM'05) (Tokyo, February 25 and 26, 2005)

Article type: Research Article

Authors: Xia, Zuo-Li^; | Sun, Bao-Liang | Zheng, Yan-Hong | Yang, Ming-Feng | Song, Xi-Jun | Hao, Fang | Zhao, Xiao-Min | Xu, Chang-Qing

Affiliations: Institute of Microcirculation, Affiliated Hospital, Taishan Medical College, Taian, Shandong 271000, China | Institute of Cerebral Microcirculation, Taishan Medical College, Taian, Shandong 271000, China | Department of Physiology, Taishan Medical College, Taian, Shandong 271000, China

Note: [] Corresponding author. E-mail: [email protected].

Abstract: The model of lymphatostatic encephalopathy was established by occluding and removing profound cervical nodes in rats, and the kinetic alteration of nitric oxide (NO), maleic dialdehyde (MDA), free radical scavenger (CuZn-SOD) and arterial systolic blood pressure were determined on different days after the blockage. The results showed that the level of NO significantly decreased at 1 day (P<0.05) and further decreased at 3, 5 and 7 day (P<0.01). The levels of MDA at 1, 3, 5 and 7 day significantly increased, but the contents of CuZn-SOD significantly decreased compared with the control (P<0.01). There was negative correlation between the levels of MDA and CuZn-SOD, but there was no relationship between MDA an NO. Arterial systolic blood pressure decreased progressively after cervical lymphatic blockage. The results showed that NO, oxide free radicals and the disturbances of the cardiovascular regulation may play important roles in lymphatostatic encephalopathy.

Keywords: Lymphatostatic encephalopathy, nitric oxide, free radical, arterial systolic blood pressure

Journal: Clinical Hemorheology and Microcirculation, vol. 34, no. 1-2, pp. 207-211, 2006