Clinical Hemorheology and Microcirculation - Volume 3, issue 2
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Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of
Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of
Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to
Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of
Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
Abstract: Although plasma fibrinogen levels are known to increase during pregnancy, only limited hemorheological information regarding this condition appears to exist in the literature. The present study was thus designed to measure specific rheologic parameters (i.e., the extent and the rate of RBC aggregation, plasma viscosity, plasma fibrinogen concentration) in normal pregnancy and in pregnancy complicated by diabetes and pre-eclampsia. Our results indicate: 1) increased RBC aggregation and plasma fibrinogen levels in pregnancy versus non-pregnant controls; 2) when compared to normal pregnancy, late diabetic pregnancy was associated with an increased rate of RBC aggregation and pre-delivery diabetic pregnancy with both an…increased rate and extent of erythrocyte aggregation; 3) pre-eclamptic pregnancy differed from normal pregnancy only by having a lower plasma viscosity. All groups of pregnant women had increased levels of high molecular weight fibrinogen-fibrin complexes (HMWFC), with the maximum increase noted in the late pregnancy diabetic population; the influence of HMWFC on RBC aggregation is discussed.
Keywords: RBC Aggregation, Normal pregnancy, Diabetic pregnancy, Pre-eclamptic pregnancy, Fibrinogen
Abstract: Dilute suspensions of EDTA anticoagulated red blood cells from 32 patients with polycythemia vera were filtered through 5 µm polycarbonate filters in a constant flow system. When the buffy coat alone was removed the remaining white cells had a considerable influence on the filtration behaviour. A method was developed in which 95% of the white cells were removed by prefiltration of the whole blood through a natural cotton-wool filter. In further experiments the filterability of red cells from 19 polycythemic patients was compared with that from controls and found to show no significant difference. The small number of remaining white…cells still influenced the results and it is suggested that white cell artefacts may explain some of the difference previously reported by this technique.
Keywords: Red cell filtration, leukocyte, polycythemia
Abstract: The authors realized from twelve patients with cardiac diseases, a kinetic study of the erythrocyte filtration flow (E.F.F) during and after extracorporeal circulation (E.C.C) surgery. In most of the cardiac patients, E.F.F was lower than in the control group; since the beginning of anesthesia, E.F.F increased and remained significantly higher throughout E.C.C with a maximal value at the 30th mn (2 p < 0.001). At the end of E.C.C and in the post-operative period, E.F.F decreased below the reference values (2 p < 0.001). In order to explain this E.F.F kinetic the authors discussed the influence of the following…factors: a) factors acting on the whole blood viscosity: hematocrit decrease and fibrinogen decrease enhanced the E.F.F; b) factors acting on the erythrocyte deformability: hypothermia and Pv¯O2 increase are positively correlated with E.F.F (2 p < 0.001); alcalosis is closely related to E.F.F decrease and there is a significant relationship (2 p < 0.05) between 2,3-DPG decrease and E.F.F decrease in the post-operative period (3th hour); the decrease of internal red cell viscosity, related to the mean corpuscular hemoglobin concentration (MCBC) enhanced erythrocyte deformability (2 p < 0.01). Total hemodilution seems to be important in explaining the E.F.F increase during E.C.C. It could also intervene in the post-operative period by limiting the 2,3-DPG decrease and so the E.F.F decrease.
Abstract: The relation between deformability of RBCs and oxygen transfer is investigated by comparing RBCs from normal and Fallot donors. In the present modelization of the biological system, the flow is generated by a platinum disc electrode rotated, under laminar conditions, in a RBC suspension, and the oxygen transfer to the wall is measured by the rate of the electrochemical reduction of oxygen to water. Deformability, measured by filterability, is shown to be lower for Fallot than for normal RBCs. The results on oxygen reduction reveal that an increase in the deformability of the RBC gives rise to an increase of…oxygen transfer which corresponds mainly to an increase of the diffusion coefficient of oxygen in the suspending medium.
Abstract: A gravity filtration technique, using cotton wool from an Imugard IG500 filter, has been developed for removal of leucocytes and platelets from EDTA- or heparin-anticoagulated blood prior to studies of erythrocyte deformability. This technique removed 98.1% of leucocytes and 99.8% of platelets, without causing haemolysis, and was found to be superior to alternative methods of cell removal including centrifugation, column sedimentation, and filtration through cellulose. The erythrocytes recovered after filtration through cotton wool were representative of the original blood sample, as judged by cell size distribution, and there was no selective removal of reticulocytes, irreversibly sickled cells, or Heinz-body containing…cells.