Clinical Hemorheology and Microcirculation - Volume 2, issue 4
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Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of
Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of
Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to
Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of
Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
Abstract: The radial spreading time of a red cell suspension within a filter paper correlates with the filtration time as assessed by a conventional funnel filtration technique. 25 µl of a red cell suspension was dispensed onto an annularly suspended filter paper and the radial spreading time recorded. The filter paper was calibrated by previous measurement of the spreading time for the suspending solution (calibration time). A linear correlation between calibration time and radial spreading time was found for individual red cell suspensions as well as for a population of normal individuals (p < 0.001). The quotient radial spreading time/calibration…time represented a measure of relative red cell suspension viscosity. Technical equipment and procedure were extremely simple and measurements could be made with as little as 1 ml of donor blood, allowing the application to problems of pediatrics and neonatology.
Abstract: A group of polymers has been synthesized using hemoglobin from out-dated blood and starch. These new materials have been characterized with respect to molecular weight, intrinsic viscosity and hemoglobin content. Preliminary studies on the starch-hemoglobin polymers indicate that these compounds will transport oxygen to the tissues, have satisfactory oncotic properties and provide adequate hemodilution when used in transfusion.
Abstract: To verify the modifications of the haemostatic balance in 9 patients with Systemic Lupus Erythematosus, complex Factor VIII, fibrinolysis activators and inhibitors were investigated. The influence of corticosteroid therapy was also assessed. All these determinations were carried out both in patients and in 10 healthy volunteers,before and after stasis. After stasis in SLE patients complex Factor VIII showed a significantly increase which seems to point to a thrombogenic condition, while the fibrinolytic activity showed a tendency to increase. These results were evaluated in order to the possible role of steroid treatment.
Abstract: A method of measuring red-cell filterability is described in which washed, human red cells, substantially freed of white cells and platelets and suspended in isotonic phosphate-buffered saline at 20–220°, are delivered at a constant rate and concentration to a membrane with 3 μ m diameter pores. Filterability is determined as a pressure increase on the upstream side of the membrane arising from the passage of cells through the pores. Application of the technique to iron-deficient red cells demonstrated that at a fixed concentration of cells they are more filterable than normal. Published reports which show them to be less filterable…probably arise from the use of a fixed haematocrit rather than a fixed red-cell concentration to express the results.
Keywords: Filterability, Red cells, Iron deficiency