Thrombogenesis and fibrinolysis: Risk in systemic lupus erythematosus (SLE) patients?

Article type: Research Article

Authors: Bertaglia, E. | Guerra, C. | Vertolli, U. | Varchetta, V. | Azzurro, M. | Belmonte, P.

Affiliations: Clinica Medica I Policlinico Universitario, Padova, Italia

Note: [] Accepted by: Editor J. Dormandy

Abstract: To verify the modifications of the haemostatic balance in 9 patients with Systemic Lupus Erythematosus, complex Factor VIII, fibrinolysis activators and inhibitors were investigated. The influence of corticosteroid therapy was also assessed. All these determinations were carried out both in patients and in 10 healthy volunteers,before and after stasis. After stasis in SLE patients complex Factor VIII showed a significantly increase which seems to point to a thrombogenic condition, while the fibrinolytic activity showed a tendency to increase. These results were evaluated in order to the possible role of steroid treatment.

Keywords: SLE, Factor VIII, Fibrinolysis

DOI: 10.3233/CH-1982-2413

Journal: Clinical Hemorheology and Microcirculation, vol. 2, no. 4, pp. 367-371, 1982