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Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of
Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials.
The aim of biorheological research is to determine and characterize the dynamics of physiological processes at all levels of organization. Manuscripts should report original theoretical and/or experimental research promoting the scientific and technological advances in a broad field that ranges from the rheology of macromolecules and macromolecular arrays to cell, tissue and organ rheology. In all these areas, the interrelationships of rheological properties of the systems or materials investigated and their structural and functional aspects are stressed.
The scope of papers solicited by
Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.
Biorheology invites papers in which such 'molecular biorheological' aspects, whether in animal or plant systems, are examined and discussed. While we emphasize the biorheology of physiological function in organs and systems, the biorheology of disease is of equal interest. Biorheological analyses of pathological processes and their clinical implications are encouraged, including basic clinical research on hemodynamics and hemorheology.
In keeping with the rapidly developing fields of mechanobiology and regenerative medicine,
Biorheology aims to include studies of the rheological aspects of these fields by focusing on the dynamics of mechanical stress formation and the response of biological materials at the molecular and cellular level resulting from fluid-solid interactions. With increasing focus on new applications of nanotechnology to biological systems, rheological studies of the behavior of biological materials in therapeutic or diagnostic medical devices operating at the micro and nano scales are most welcome.
Abstract: A trend of engineering approach to physiology is to predict physiological events with mathematical accuracy. In order to achieve this objective, it is necessary to know the structure of the organs and the mechanical properties of their components; i.e., the anatomy, histology, and rheology of the system. Then one must perform the analysis rationally, avoiding ad hoc assumptions as far as possible. To illustrate this aspiration, procedure, labor, and rewards, the case of pulmonary circulation is discussed. For cat lung, anatomical and rheological data were collected; biorheological analysis was done, and physiological experiments were compared with theoretical predictions. Satisfactory results…were obtained. The case of flow under zone 2 condition, when “waterfall phenomenon” prevails, is especially interesting. We proved theoretically that any partial collapse of an interalveolar septum is unstable. Hence if a collapse is initiated in an interalveolar septum, the whole septum will be collapsed. From this theoretical result, the pressure-flow relationship is predicted and is shown to agree well with the experiment. New trends toward cell biology and molecular approach are evident in this meeting. Some anticipated trends are, however, still slow in coming.
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Keywords: Poiseuille equation, fifth power law, pulmonary circulation, waterfall phenomenon
DOI: 10.3233/BIR-1986-23609
Citation: Biorheology,
vol. 23, no. 6, pp. 573-587, 1986
Abstract: Network theory has evolved from the simplest rubber materials and is just entering the biological area. The existing theories are studied and the modifications required for biological applications are reviewed. The issues involved are: the balance between entropy and internal energy, the rigidity and flexibility of molecules, the stability of the networks, the origin of the intermolecular forces and the entanglement problems of swelling and precipitation.
Abstract: This paper provides a general over-view to introduce the subsequent papers on particular topics of plant transport. A revised statement is given of the transport processes reviewed in Ann. Rev. Fluid Mech., 9 , 275 (1977), outlining the tissue and cell structures of the plant body which carry out the long distance movements of water, mineral nutrients, and organic material. Some of the questions posed in that review are now better understood, e.g. the breaking of xylem water columns under tension, the loading of sugars into phloem in leaves, and the dissemination of water in leaf veins. Intractable questions remain…to which there are no agreed answers, especially the organisation within phloem sieve tubes and the relative roles of the apoplast and symplast in the uptake of water and mineral ions by roots. New techniques are available for tracing water-soluble substances at high resolution in microscopic preparations which may lead to the resolving of some of these questions.
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Abstract: Blood rheology was studied in patients with acute myocardial infarction (AMI) and essential hypertension (EH), and the results were correlated with in vivo hemodynamic functions. Blood viscosity (η B ) was elevated as a result of sequential changes of a number of parameters, including increases in hematocrit, plasma fibrinogen and α 2 -globulin, an enhancement of red cell aggregation and a reduction of red cell filterability in plasma. Total peripheral resistance (TPR) was elevated upon admission, due to increases in both the vascular hindrance (Zs ) and η B . During recovery, the η B became normalized; alterations in…η B were accompanied by parallel changes in TPR and an inverse change in plasma volume (PV). In EH patients, the increase in η B showed a correlation with arterial pressure. For both established and borderline hypertensives, the rheological changes were most prominent in the high renin subgroups. In mild EH, the elevation of η B was compensated by a decrease in Zs (vasodilation), keeping the TPR essentially normal. In EH with higher arterial pressure, the elevation of η B was accompanied by a normal Zs without compensatory vasodilation, and hence TPR rose to exacerbate the hypertension. These results suggest that the elevation of η B may be an early event in the development of EH and that its role must be considered with concurrent cardiovascular functions. In EH there is a significant correlation between left ventricular mass and η B . Experimental manipulations of the hematocrit level in spontaneously hypertensive rats led to a corresponding variation of arterial pressure. The available data implicate a significant role of η B in the pathophysiology of AMI and EH. Further interdisciplinary, longitudinal studies are needed tin order to unravel the complicated pathophysiological changes in myocardial infarction and hypertension.
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