Affiliations: Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest, Romania | S. Nicolau Institute of Virology, Bucharest, Romania | Microbiology Department, Faculty of Biology, University of Bucharest, Bucharest, Romania
Note: [] Address for correspondence: Alexandru Mihai Grumezescu, Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1-7 Gh. Polizu st., Bucharest, Romania. Tel.: +40765349326; E-mail: [email protected]
Abstract: The synthesis of carboxymethyl-cellulose/magnetite (CMC/Fe3O4) was carried out. This magnetic hybrid material was characterized by infrared spectroscopy, scanning electron microscopy and X-ray diffractometry. The adsorption of norfloxacin and cefotaxim antimicrobial substances (ATB) onto the CMC/Fe3O4 was performed in order to investigate the capacity of the magnetic scaffold to improve the antimicrobial activity of the respective therapeutic agents, assessed by an in vitro quantitative assay. The obtained results proved that CMC/Fe3O4/ATBs might be a promising candidate for the development of efficient and cheap antimicrobial drugs carriers under magnetic field.
Keywords: CMC/Fe3O4, magnetic scaffold, drug delivery, antimicrobial activity, biocompatibility
