Biochemical kinetics of cell proliferation regulated by extremely low frequency electromagnetic field

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 2nd International Conference on Biomedical Engineering and Biotechnology, 11–13 October 2013, Wuhan, China

Article type: Research Article

Authors: Geng, D.Y.^; | Li, C.H. | Wan, X.W. | Xu, G.Z.

Affiliations: Province-Ministry Joint Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability, Hebei University of Technology, Tianjin, China

Note: [] Corresponding author. E-mail: [email protected].

Abstract: To study the mechanism of cells subjected to external electromagnetic fields, the expression of cyclin kinase inhibitor p27 is analyzed in the four cell cycle phases. The regulatory functions are investigated in gap phase1 to synthesis, gap phase 2 to mitotic phase and post mitotic phase transition in the mammalian cell cycle processes. A mathematical model is developed to meet the general cell cycle regulatory network based on the molecular dynamics method. Phase plane analysis results show that the p27 over-expression can lead to the hysteresis effect of cell cycle processes and phase transition delay. It is an universal approach to predict the key regulatory gene in signal transduction pathway.

Keywords: Electromagnetic fields, Mathematical model, Molecular dynamics method, Cell cycle, Phase plane analysis

DOI: 10.3233/BME-130943

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 1, pp. 1391-1397, 2014