Hypertension, hypercoagulability and the metabolic syndrome: A cluster of risk factors for cardiovascular disease

Issue title: Selected papers from the 4th China–France Biotherapy and Regenerative Medicine International Symposium, Wuhan, June 2011

Article type: Research Article

Authors: Mao, Xianqing | Ait-Aissa, Karima | Lagrange, Jeremy | Youcef, Gina | Louis, Huguette^;

Affiliations: INSERM, U961, Vandoeuvre-les-Nancy, France | Nancy Université, Nancy, France

Note: [] Address for correspondence: Huguette Louis, Inserm U961, Faculté de Médecine, 9 avenue de la Forêt de Haye, 54500 Vandoeuvre-les-Nancy, France. Tel.: +33 3 83683631; Fax: +33 3 83683639; E-mail: [email protected].

Abstract: Cardiovascular disease (CVD) is one of the main causes of mortality in the world representing around 30% of all deaths. It constitutes also an important factor in morbidity and incapacity. There are several related CVD risk factors such as hypertension, metabolic syndrome (MetS) and hypercoagulability. The exact mechanisms that underlie the relation between those factors and CVD are not sufficiently known yet; pathogenic explanations are lacking also for the mechanisms relating metabolic factors to insulin resistance (IR) and the association with the development of atherosclerosis and thrombosis. The possible links between hypertension, hemostasis alterations and MetS are examined in this report.

Keywords: Hypertension, hypercoagulability, metabolic syndrome, animal model

DOI: 10.3233/BME-2012-0688

Journal: Bio-Medical Materials and Engineering, vol. 22, no. 1-3, pp. 35-48, 2012