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Article type: Research Article
Authors: Athani, Abdulgaphura | Ghazali, N.N.N.a; | Anjum Badruddin, Irfanb; | Kamangar, Sarfarazb | Salman Ahmed, N.J.c | Honnutagi, Abdulrazakd
Affiliations: [a] Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia | [b] Mechanical Engineering Department, College of Engineering, King Khalid University, Abha, Kingdom of Saudi Arabia | [c] Department of Mechanical Engineering, HMS Institute of Technology, Tumkur, India | [d] Department of Civil Engineering, Anjuman-I-islam’s Kaleskar Technical Campus (AIKTC), New Mumbai, India
Correspondence: [*] Corresponding authors: N.N.N. Ghazali, Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia. E-mail: [email protected]. Irfan Anjum Badruddin, Mechanical Engineering Department, College of Engineering, King Khalid University, Abha, Kingdom of Saudi Arabia. E-mail: [email protected]
Abstract: BACKGROUND:Coronary arteries disease has been reported as one of the principal roots of deaths worldwide. OBJECTIVE:The aim of this study is to analyze the multiphase pulsatile blood flow in the left coronary artery tree with stenosis. METHODS:The 3D left coronary artery model was reconstructed using 2D computerized tomography (CT) scan images. The Red Blood Cell (RBC) and varying hemodynamic parameters for single and multiphase blood flow conditions were analyzed. RESULTS:Results asserted that the multiphase blood flow modeling has a maximum velocity of 1.017 m/s and1.339 m/s at the stenosed region during the systolic and diastolic phases respectively. The increase in Wall Shear Stress (WSS) observed at the stenosed region during the diastole phase as compared during the systolic phase. It was also observed that the highest Oscillatory Shear Index (OSI) regions are found in the downstream area of stenosis and across the bifurcations. The increase in RBCs velocity from 0.45 m/s to 0.6 m/s across the stenosis was also noticed. CONCLUSION:The computational multiphase blood flow analysis improves the understanding and accuracy of the complex flow conditions of blood elements (RBC and Plasma) and provides the progression of the disease development in the coronary arteries. This study helps to enhance the diagnosis of the blocked (stenosed) arteries more precisely compared to the single-phase blood flow modeling.
Keywords: Computed tomography (CT), computational fluid dynamics (CFD), single and multiphase blood flow, RBC, left coronary artery
DOI: 10.3233/BME-211333
Journal: Bio-Medical Materials and Engineering, vol. 34, no. 1, pp. 13-35, 2023
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