Bisphosphosphonate-calcium phosphate cement composite and its properties

Article type: Research Article

Authors: Parasaram, Vaideesh^a | Chowdhury, Aniqa^a | Karamched, Saketh R.^a | Siclari, Steven^a | Parrish, Joe^a | Nosoudi, Nasim^{a; b;}

Affiliations: [a] Department of Bioengineering, Clemson University, Clemson, South Carolina, USA | [b] Department of Biomedical, Industrial and Human Factors Engineering, Wright State University, Dayton, Ohio, USA

Correspondence: [*] Corresponding author: Nasim Nosoudi, Department of Biomedical, Industrial and Human Factors Engineering, Russ Engineering Center 207, 3640 Colonel Glenn Hwy, Dayton, OH 45435, USA. E-mail: [email protected]

Abstract: Calcium phosphate cement (CPC) has been studied extensively due to its bioactivity and biodegradability. CPC is typically made by a combination of multiple calcium phosphates that form a paste that sets and hardens in the body after being combined with either water or an aqueous solution. It is highly moldable and easily manipulated, and CPCs possess osteoconductive properties. Due to these characteristics, CPCs offer great promise in bone grafting applications. CPC combined with drugs has a great potential as drug delivery system and has been studied extensively. In this review we have focused on Bisphosphonate-CPC drug delivery system. In addition, we introduce and discuss the potential of studying other bisphosphonates.

Keywords: Bisphosphonates, calcium phosphate cement (CPC), drug delivery, bone tissue engineering

DOI: 10.3233/BME-191055

Journal: Bio-Medical Materials and Engineering, vol. 30, no. 3, pp. 323-331, 2019