Thyroid hormone disorders and sepsis

Issue title: Selected papers from the 6th China–France International Symposium “Stem Cells and Regenerative Medicine” and the first meeting of the France–China International CNRS Network (GDRI) CeSMeR, Nancy, 10–13 July 2016

Guest editors: J.-F. Stoltz, J. Magdalou and D. Bensoussan

Article type: Research Article

Authors: Luo, Bin^{a; *} | Yu, Zhui^{b; *} | Li, Yinping^{a; **}

Affiliations: [a] Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, 430071, P.R. China | [b] Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430071, P.R. China

Correspondence: [**] Corresponding author: Yinping Li, School of Basic Medical Sciences of Wuhan University, #185 Donghu Road, Wuhan 430071, P.R. China. E-mail: [email protected].

Note: [*] The two authors contributed equally to the work.

Abstract: Sepsis is a systemic inflammatory response syndrome with high mortality, which results from severe infection and can lead to secondary organ dysfunction. It is one of the most common cause of death in intensive care unit. Clinical reports have shown that sepsis was often accompanied by thyroid dysfunction, which is called “low triiodothyronine (T3)” syndrome and characterized by decreased blood total T3 and free T3, and by normal or decreased thyroxine (T4) and thyroid stimulating hormone (TSH). This syndrome may greatly affect the prognosis of patients with sepsis. The main purpose of this review is to illustrate the role of thyroid hormone disorder in the development and prognosis of sepsis.

Keywords: Sepsis, thyroid hormone, low T3 syndrome, organ dysfunction

DOI: 10.3233/BME-171646

Journal: Bio-Medical Materials and Engineering, vol. 28, no. s1, pp. S237-S241, 2017