Multiphysics of bone remodeling: A 2D mesoscale activation simulation

Issue title: Selected papers from the 6th China–France International Symposium “Stem Cells and Regenerative Medicine” and the first meeting of the France–China International CNRS Network (GDRI) CeSMeR, Nancy, 10–13 July 2016

Guest editors: J.-F. Stoltz, J. Magdalou and D. Bensoussan

Article type: Research Article

Authors: Spingarn, C.^a | Wagner, D.^{a; b} | Rémond, Y.^a | George, D.^{a; *}

Affiliations: [a] Laboratoire des Sciences de l’Ingenieur, de l’Informatique et de l’Imagerie (Icube), Université de Strasbourg, CNRS, 67000 Strasbourg, France | [b] Faculté de Chirurgie Dentaire, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France

Correspondence: [*] Corresponding author. E-mail: [email protected].

Abstract: In this work, we present an evolutive trabecular model for bone remodeling based on a boundary detection algorithm accounting for both biology and applied mechanical forces, known to be an important factor in bone evolution. A finite element (FE) numerical model using the Abaqus/Standard® software was used with a UMAT subroutine to solve the governing coupled mechanical-biological non-linear differential equations of the bone evolution model. The simulations present cell activation on a simplified trabeculae configuration organization with trabecular thickness of 200µm. For this activation process, the results confirm that the trabeculae are mainly oriented in the active direction of the principal mechanical stresses and according to the principal applied mechanical load directions. The trabeculae surface activation is clearly identified and can provide understanding of the different bone cell activations in more complex geometries and load conditions.

Keywords: Mechanobiology, bone, remodeling, FEM, trabecula, multiphysics

DOI: 10.3233/BME-171636

Journal: Bio-Medical Materials and Engineering, vol. 28, no. s1, pp. S153-S158, 2017