Affiliations: [a] Medical and Dental Device Technology Incubation Center, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan | [b] Institute for Materials Research, Tohoku University, Sendai, Japan | [c] Department of Instrumental Analysis Research Center, Tokyo Medical and Dental University, Tokyo, Japan | [d] Department of Orthopaedic Surgery, Kawakita General Hospital, Tokyo, Japan
Correspondence:
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Corresponding author: Wei Wang, Medical and Dental Device Technology Incubation Center, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan. Tel./Fax: +81 3 5280 8044; E-mail: [email protected].
Abstract: Ti-based bulk metallic glasses are reported with high strength, low Young modulus and high corrosion resistance, suggesting their potentials in biomedical applications. However a thorough in vivo evaluation of its biocompatibilities has not been conducted yet. In this study, we implanted bars of Ti-based bulk metallic glass in the femoral bone of rats, followed up local tissue reaction as well as its component ions’ diffusion in local area and whole body. The Ti-based BMG (Ti40Zr10Cu34Pd14Sn2) alloy exhibited favorable features of both high strength and high elasticity. In vivo implant evaluation showed that it has a good tissue compatibility, equivalent bone integration and bonding ability with Ti sample. No component ion diffusion was detected up to 3 months post implantation. The possibility and efficacy of its use for bone implant is confirmed. Thus further long term implant study is recommended.
Keywords: Bulk metallic glass, Ti-based alloy, in vivo
