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Security assessment of magnesium alloys used as biodegradable implant material

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 4th International Conference on Biomedical Engineering and Biotechnology, 18–21 August 2015, Shanghai, China

Guest editors: Feng Liu, Dong-Hoon Lee, Ricardo Lagoa and Sandeep Kumar

Article type: Research Article

Authors: Sun, X.a | Cao, Z.Y.a; * | Liu, J.G.b | Feng, C.c

Affiliations: [a] Department of Materials Science and Engineering, Jilin University, Changchun 130025, China | [b] Joint Surgery Department, Norman Bethune No.1 Hospital, Jilin University, Changchun 130000, China | [c] Changchun Limei Technology Development Company Limited, Changchun 130000, China

Correspondence: [*] Address for correspondence: Z.Y. Cao, Department of Materials Science and Engineering, Jilin University, Changchun 130025, China. Tel.: +86 431 85095852; Fax: +86 431 85095876; E-mail: [email protected].

Keywords: Risk assessment, biodegradation, magnesium alloys, biocompatibility

DOI: 10.3233/BME-151297

Journal: Bio-Medical Materials and Engineering, vol. 26, no. s1, pp. S119-S127, 2015

Published: 2015
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The security risk of magnesium alloys used as biodegradable implant material was evaluated in this study. Dose-response assessment was conducted by using toxicological data from authoritative public health agencies (World Health Organization) and assuming 1~3 years of uniform corrosion. Through modification calculation, the tolerable corrosion rate of biodegradable magnesium alloys in vivo was proposed, which theoretically ensured the bio-safety of the degradation products. The tolerable limits corresponding to various component elements in magnesium alloys were considered separately, although there are deficits in the toxicological data of some component elements. The influence of corrosion on the strength of magnesium alloys was evaluated, which would contribute to the rationally utilization of magnesium alloys as degradable implant materials. This study illustrates that not only toxicological calculations but also mechanical performance should be taken into consideration when developing novel degradable metallic implant.

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