Bone defects and future regenerative nanomedicine approach using stem cells in the mutant Tabby mouse model
Issue title: Selected Papers from the 5th China–France International Symposium “Stem Cells: From Bench to Bedside”, 12–14 December 2013, Kunming, China
Affiliations: French National Institut of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, Strasbourg, France | Université de Strasbourg, Faculté de Chirurgie Dentaire, Pôle de Médecine et de Chirurgie Bucco-Dentaires, Strasbourg, France | Unité de Thérapie Cellulaire et Tissus, CHU Brabois, Nancy, France
Note: [] Address for correspondence: François Clauss, French National Institut of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR 1109, 67085 Strasbourg Cedex, France. E-mail: [email protected]
Abstract: X-linked Hypohidrotic Ectodermal Dysplasia (XLHED) is associated to a large spectrum of ectodermal and extra-ectodermal symptoms, especially craniofacial bone morphological, structural and metabolic anomalies. This skeletal phenotype described in affected patients and in the Ta mutant mouse model leads to craniofacial dysmorphies, endosseous implants and jaw bone grafts complications. Bone tissue bioengineering based on the use of PCL synthetic nanofibrous membrane and BMP nanoreservoirs appears as an original and promising approach to prevent such complications in the context of dysfunctional bone. Use of osteoblasts or stem cells seeded biomembranes appears as another strategy developed on the Tabby (Ta) model of XLHED. The Ta mouse experimental model is used to study the jaw bone response during the post-operative period after bone lesion and placement of synthetic PCL membrane functionalized with nanoreservoirs embedding different BMPs dimers or seeded with living cells.
Keywords: Ectodermal dysplasia, bone regeneration, tissue engineering
