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Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model
Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 3rd International Conference on Biomedical Engineering and Biotechnology, 25–28 September 2014, Beijing, China
Article type: Research Article
Authors: Ji, Bing; | Yang, Qing | Genever, Paul G. | Fagan, Michael J.
Affiliations: School of Control Science and Engineering, Shandong University, 17923 Jingshi Road, Jinan, 250061, People's Republic of China | Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwuweiqi Road, Jinan, 250021, People's Republic of China | Department of Biology, University of York, Heslington, York, YO10 5DD, UK | School of Engineering, University of Hull, Cottingham Road, Hull, HU6 7RX, UK
Note:  Corresponding author: Bing Ji, School of Control Science and Engineering, Shandong University, 17923 Jingshi Road, Jinan, 250061, People's Republic of China. Tel.: 86-0531-88396816-806; Fax: +86-0531-88396813; E-mail: [email protected]
Keywords: Multiple myeloma, MM-induced bone disease, bisphosphonates, anti-tumour, computational model
Journal: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 3373-3378, 2014
Multiple myeloma (MM)-induced bone disease is mortal for most MM patients. Bisphosphonates are first-line treatment for MM-induced bone disease, since it can inhibit osteoclast activity and the resultant bone resorption by suppressing the differentiation of osteoclast precursors into mature osteoclasts, promoting osteoclast apoptosis and disrupting osteoclast function. However, it is still unclear whether bisphosphonates have an anti-tumour effect. In our previous work, a computational model was built to simulate the pathology of MM-induced bone disease. This paper extends this proposed computational model to investigate the efficacy of bisphosphonates treatment and then clear the controversy of this therapy. The extended model is validated through the good agreement between simulation results and experimental data. The simulation results suggest that bisphosphonates indeed have an anti-tumour effect.