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Ambulatory monitoring derived blood pressure variability and cardiovascular risk factors in elderly hypertensive patients

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 3rd International Conference on Biomedical Engineering and Biotechnology, 25–28 September 2014, Beijing, China

Article type: Research Article

Authors: Magdás, Annamária; | Szilágyi, László | Belényi, Boglárka | Incze, Alexandru

Affiliations: County Clinical Hospital–Internal Medicine Department IV, University of Medicine and Pharmacy Tîrgu Mures, Str. Gh. Marinescu Nr. 38, 540139 Tîrgu Mures, Romania | Faculty of Technical and Human Sciences, Sapientia–Hungarian University of Transylvania, Sos. Sighisoarei 1/C, 540485 Tîrgu Mures, Romania

Note: [] Corresponding author: Annamária Magdás, County Clinical Hospital–Internal Medicine Department IV, University of Medicine and Pharmacy Tîrgu Mures, Str. Gh. Marinescu Nr. 38, 540139 Tîrgu Mures, Romania. Tel.: 40-740-962529; Fax: 40-265-206211; E-mail: [email protected].

Keywords: ABPM, blood pressure variability, cardiovascular risk factors, elderly

DOI: 10.3233/BME-141071

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 2563-2569, 2014

Published: 2014
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Abstract

Hypertension in the elderly is characterized by isolated systolic hypertension and high variability, but its clinical significance is not yet fully understood. The goal of this paper was to assess circadian blood pressure variability (BPV) in elderly hypertensives, and to determine its relationship to cardiovascular risk factors. To achieve this goal, a number of 75 inefficiently treated hypertensive patients were studied, 45 elderly, aged over 60 years, 30 middle-aged, younger than 60 years. After 24-hour ambulatory blood pressure monitoring (ABPM), blood pressure (BP) values, pulse pressure (PP), morning surge were compared between the groups. BPV was calculated using average real variability (ARV). The relationships between BPV, pulse pressure, left ventricular mass index (LVMI), and cardiovascular risk factors were assessed in both groups. As a result, it was found that left ventricular mass (p=0.01), PP, morning surge, 24-hour systolic ARV were significantly higher in the elderly group (p<0.05). In both groups, higher 24-hour BPV was associated with an increase in LVMI. In the elderly population 24-hour BPV was positively correlated to increased PP, total cholesterol and triglyceride levels (p<0.05). Moreover, it was concluded that ABPM-derived BP variability index could be an early predictive marker of end-organ damage in hypertension. Its reduction might be an important objective of hypertension management in elderly.

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