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Electrospun quercetin-loaded zein nanoribbons

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 3rd International Conference on Biomedical Engineering and Biotechnology, 25–28 September 2014, Beijing, China

Article type: Research Article

Authors: Li, Xiao-Yan | Shi, Chen-Jie | Yu, Deng-Guang; | Liao, Yao-Zu | Wang, Xia;

Affiliations: School of Materials Science & Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China | School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai 200093, China | School of Chemistry, University of Bristol, Bristol, England BS8 1TS, UK

Note: [] Corresponding authors: Deng-Guang Yu, School of Materials Science & Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China. Tel.: +86-021-55274069; Fax: +86-021-55270632; E-mail: [email protected].

Note: [] Xia Wang, School of Materials Science & Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China. Tel.: +86-021-55271686; Fax: +86-021-55270632; E-mail: [email protected].

Keywords: Zein, quercetin, nanoribbons, coaxial electrospinning, drug delivery

DOI: 10.3233/BME-141011

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 2015-2023, 2014

Published: 2014
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Abstract

This study investigates quercetin-loaded zein nanoribbons, which were fabricated using different types of electrospinning processes. Using ethanol aqueous solutions as sheath fluids, the widths of quercetin-loaded zein nanoribbons (D, nm) could be manipulated simply through the adjustment of water contents(C) in the sheath fluids according to an equation of D=958−8.01C(r=0.9977), as indicated by the field emission scanning electron microscopic observations. X-ray diffraction and attenuated total reflectance Fourier transform infrared analysis suggested that the quercetin presented in the zein nanoribbons in an amorphous state due to their high compability resulted from hydrogen bonds. In vitro dissolution tests verified that nanoribbons from the coaxial process and single fluid process could provide drug sustained release profiles via a typical Fickian diffusion mechanism, and the former exhibited better performance than the later in terms of small initial burst effect and leveling-off release. Coaxial electrospinning with solvents can expand the capability of electrospinning in generating nanoproducts and provide a way for improving the nanoproducts' quality and functional performance.

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