Affiliations: Belorussian Center of Cardiology, R.Luxemburg str., 110, Minsk 220036, Belarus
Note: [] Corresponding author: Dr. Elena Konstantinova, Belorussian Center of Cardiology, Rakovskaya str., 27-47, 220004 Minsk, Belarus. Tel.: +375 17 208 69 56; Fax: +375 17 230 63 10; E-mail: [email protected].
Abstract: The results of some researches specify the important role of blood rheological properties changes in arterial hypertension (AH) pathogenesis. The goal of our study is to investigate the parameters of hemorheology and platelet aggregation in patients with various grade of AH. The study was carried out on 27 patients with grade 1 AH (group 1), 24 patients with grade 2 AH (group 2) and 29 healthy subjects (group 3). In patients of these groups, we evaluated erythrocytes deformability, red blood cells and platelets aggregation, blood and plasma viscosity. Using intra-vital computer-associated microscopic system we investigated microcirculation of bulbar conjunctiva. We observed that the rate of ADP-induced platelets aggregation is higher in group 1 as compared to groups 2 and 3. In groups 1 and 3, red blood cells rigidity index is significantly lower as compared to group 2. Erythrocyte aggregability is higher in group 2 in comparison with groups 1 and 3. The results obtained demonstrate that mild hypertension is associated with the rise of platelets aggregability, moderate hypertension is accompanied by the reduction of red blood cells deformability and increase of erythrocyte aggregability. These data may reflect differences in conditions for the formation of microcirculation disorders in AH of various grade.
