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Article type: Research Article
Authors: Agosti, R.a | D’Etturre, M.b | Cherubini, P.a | Clivati, A.a | Bozzoni, M.c | Longhini, E.c
Affiliations: [a] Laboratorio di Emoreologia, Servizio di Broncopneumologia e Fisiopatologia Respiratoria, Italy | [b] Laboratorio Analisi, Italy | [c] Divisione Medica “D. e G. Campari”, Ospedale “Citta‘ di Sesto San Giovanni”, V.le Matteotti, 83 – 20099 Sesto S. Giovanni, Milano, Italy
Note: [] Accepted by: Editor S. Chien
Abstract: We studied blood and plasma viscosity, hematocrit, erythrocyte aggregation index and plasma protein fractions in 26 healthy subjects. We found a significant positive linear correlation between hematocrit and blood viscosity at each of the considered shear rates (low shear range), and a significant negative linear correlation between hematocrit and erythrocyte aggregation index. Furthermore, we found a significant linear correlation between a multiparameter index and erythrocyte aggregation index so that fibrinogen and a-2-globulins seemed to have an enhancing effect on rouleaux forming whereas albumin and hematocrit seemed to play an opposing role. Physiopathological and clinical aspects of these findings were discussed.
Keywords: erythrocyte aggregation, blood viscosity, hematocrit, low shear, plasma proteins
DOI: 10.3233/CH-1988-8508
Journal: Clinical Hemorheology and Microcirculation, vol. 8, no. 5, pp. 603-620, 1988
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