Plasma lipid levels, blood rheology, platelet aggregation, microcirculation state and oxygen transfer to tissues in young and middle‐aged healthy people
Issue title: Selected proceedings of the 12th European Conference on Clinical Hemorheology, 22‐26 June 2003, Sofia, Bulgaria
Affiliations: Belorussian Center of Cardiology, Minsk, Belarus | International Sakharov Environmental University, Minsk, Belarus
Note: [] Corresponding author: Dr. Elena Konstantinova, Belorussian Center of Cardiology, R.Luxemburg Str., 110 Minsk, 220036, Belarus. Tel.: +375 17 256 69 56; Fax: +375 17 230 63 10; E‐mail: [email protected].
Abstract: It has been reported that dyslipidemia is associated with rheological and microcirculatory abnormalities in patients with ischaemic heart disease. However, it is not known how this system changes in men and women with ageing. In healthy young and middle‐aged subjects the following parameters were evaluated: total plasma cholesterol, triglycerides and HDL‐cholesterol levels, deformability of erythrocytes, red blood cell and platelet aggregations, blood and plasma viscosity, neutrophils' cytosolic [Ca$^{2+}]\tsub{i}$ and microviscosity of the bilayer's total lipid phase and the annular near‐protein zone of the membranes. Using intravital computer‐associated microscopic system we investigated the microcirculation of bulbar conjunctiva. Oxygen transfer characteristics were measured with a Radiometer TCM2 monitor. It is evident from the data obtained that in men of middle age the total plasma cholesterol and triglyceride levels are higher in comparison with other groups. The rheological behavior of red blood cell and platelet aggregations in men differ from that in women. Neutrophils activation in healthy subjects was not recorded. Our results show that changes of the blood rheological properties of men 35–50 years old can lead to disturbances of the microcirculation.
